July 12, 2023 4:00 pm

Erectile Dysfunction (ED) is a condition that affects many men globally. As surprising as it may seem, the foundation of your sexual health and, in particular, your ability to achieve and maintain an erection, begins in your brain, not just in your penis.

Also, this complex process involves multiple systems in the body working harmoniously to enable proper sexual function. One common question that arises when discussing ED is: "What type of blood work is required for a comprehensive evaluation of ED?" And this episode aims to answer that.

Episode Video

A comprehensive ED evaluation starts with understanding that achieving an erection is a complex process involving several systems: the brain, nerves, hormones, heart, blood vessels, and muscles. Therefore, for successful sexual function, all these systems must work in harmony. This starts in the brain, our largest sexual organ.

Important Comprehensive Blood Works for ED

ED Blood Work: Why Every Patient Needs It
Photographer: Hush Naidoo Jade Photography | Source: Unsplash

Comprehensive blood work evaluates all these systems, looking beyond just testosterone levels, which is a common mistake in some clinics. The purpose is to assess the complete health picture of a patient suffering from ED. So, here are some of the crucial components of comprehensive bloodwork:

Complete Blood Count (CBC)

This test measures the number of red blood cells in your body and helps detect conditions like anemia or erythrocytosis (too many red blood cells). Regular monitoring is essential, especially if you're on testosterone replacement therapy.

Hemoglobin A1C

This test measures your average blood sugar levels over the past 3 months. This bloodwork also helps detect diabetes, a condition that significantly increases the risk of ED.

Lipid Panel

This measures your total cholesterol, low-density lipoproteins (LDL) or "bad" cholesterol, and high-density lipoproteins (HDL) or "good" cholesterol levels. Thus, a healthy balance of these fats in your body is essential for maintaining good sexual health.

Thyroid Hormone Panel

This test measures your levels of thyroid stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), and reverse T3. Therefore, an imbalance in thyroid hormones can contribute to ED.


A homocysteine test measures the amount of homocysteine in a sample of your blood. Homocysteine is an amino acid. Amino acids are molecules that your body uses to make proteins. Doing this test helps evaluate your risk of developing blood clots or cardiovascular disease.

Insulin Level and Vitamin D

These tests help assess your insulin resistance and the amount of vitamin D3, an essential hormone, in your blood. Also, a deficiency in vitamin D can contribute to ED.

Hormone Testing

This includes a full spectrum of hormones involved in sexual health, including testosterone (free and total), estradiol, dihydrotestosterone (DHT), Insulin-like Growth Factor 1 (IGF-1), Insulin-like Growth Factor Binding Protein 3 (IGFPB-3), Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), and prolactin. Thus, any imbalance in these hormones can contribute to ED.

Inflammatory and Prostate Markers

Tests for C-Reactive Protein (CRP), Thyroid Peroxidase Antibody, Thyroid Globulin Antibody, and Prostate-Specific Antigen (PSA) assess your body's inflammation levels and the prostate gland's health. These are both crucial for understanding ED and overall sexual health.

Factor Five Leiden Mutation

This genetic test helps identify if you're at risk of developing blood clots, essential information before starting hormone replacement therapy.

These comprehensive blood tests provide a full health snapshot for someone experiencing ED. Also, regular follow-ups with bloodwork every four months are essential for patients undergoing testosterone replacement therapy. This will ensure effective treatment and monitoring potential side effects.

Final Thoughts

In conclusion, tackling ED requires a holistic approach that considers the patient as a whole. Rather than just merely focusing on symptoms.

Comprehensive bloodwork, as supported by various studies and experts, offers a detailed insight into a patient's health. By painting a clear picture of a patient's health, healthcare providers can provide more accurate, personalized, and effective treatment strategies.

Remember, the journey towards improved sexual health starts with understanding and addressing underlying health conditions, with comprehensive bloodwork being the guiding light.

Additional Resources

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